Measuring PD-1/PD-L1 Inhibition with BMS-1166

The inQuiQ® is a powerful instrument that enables real-time, label-free analysis of biomolecular interactions using Nanophotonic Evanescent field Sensing (NES). By capturing binding events with high sensitivity, it enables the study of protein interactions and the effect of inhibitory factors influencing these interactions. This study demonstrates the system’s capabilities by analysing the inhibition effect of the small-molecule BMS-1166 on the PD-1/PD-L1 interaction, highlighting its potential for accelerating drug discovery and biomolecular research.