Fitting 1:1 model
The binding platform your group needs sits behind a booking system, a queue, and someone else's schedule.
The inQuiQ is a benchtop system your own group operates. Warm-up takes five minutes, so a question raised in the morning can have a sensorgram behind it the same day.
Expression yields are low and every microlitre of purified protein is spoken for.
Many targets and controls are read from one small sample, and regenerable chips let a full concentration series run without a new prep.
Capital is fixed, and per-run consumables quietly take the rest of the budget.
Sensor chips are regenerable and reused across a full concentration series, and the photonic architecture keeps both the instrument cost and the running cost within reach of a single group's budget.
A pilot study becomes a screening campaign, and the instrument becomes the bottleneck.
inQuiQ 768 runs the same chemistry and the same saved methods with an autosampler for 2x96 or 2x384 well plates, up to 768 samples in series.
Label-free interaction analysis measures binding between unmodified molecules in real time. It returns affinity (KD), kinetics (kon and koff), specificity, and concentration, without a fluorescent or radioactive tag on either partner. inQuiQ measures across an affinity range of 10 pM to 10 mM.
Yes. inQuiQ can be operated by researchers as part of their existing workflow. Application scientists provide support with assay setup and method development, helping researchers get started without requiring a dedicated biophysicist.
inQuiQ uses nanophotonic evanescent field sensing (NES), like SPR, but with a different sensor architecture that integrates 16 sensors on a single photonic chip. This enables more channels and a high sensitivity while keeping instrument and consumable costs low. BLI uses a dip sensor and is generally less sensitive for small molecules and fragments and for measuring off-rates since it's lacking flow, although it can be more tolerant of unfiltered samples. For applications where sensitivity, throughput, and cost of ownership matter, inQuiQ offers a strong alternative to both approaches.
Yes. Runs return full sensorgrams with association and dissociation phases, kon, koff, and KD from single-cycle or multi-cycle kinetics, with reference channel subtraction and baseline noise typically below 0.1 RU RMS. Raw and fitted data can easily be used for figures and supplementary material.